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中国癌症防治杂志

中国癌症防治杂志 ›› 2013, Vol. 5 ›› Issue (3): 246-249.doi: 10.3969/j.issn.1674-5671.2013.03.13

• 临床研究 • 上一篇    下一篇

肝动脉化疗栓塞分别联合经皮微波凝固治疗与125I放射性粒子植入治疗原发性大肝癌的疗效观察

  

  1. 广西医科大学附属肿瘤医院介入治疗科
  • 出版日期:2013-09-25 发布日期:2013-10-10

Comparing the therapeutic efficacy of TACE combined with psychro-circulation percutaneous microwave coagulation therapy or radioactive 125I particle implantation to treat large primary liver cancer

  • Online:2013-09-25 Published:2013-10-10

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摘要： 目的 评价和比较肝动脉化疗栓塞（TACE）联合经皮微波凝固治疗（PMCT）与TACE联合125I放射性粒子植入治疗原发性大肝癌的效果。方法 46例原发性大肝癌患者接受TACE联合PMCT治疗，20例接受TACE联合125I放射性粒子植入治疗。术后2个月、3个月分别行动态增强CT复查。观察并比较两组疗效、毒副反应及并发症发生的情况。结果 综合治疗后3个月， TACE联合PMCT组的有效率为82.61%，明显高于TACE联合125I放射性粒子植入组的有效率55.00%（P<0.05） 。两组的临床总控制率分别为93.47%、85.00%（P>0.05）。两组发生的毒副反应无明显差异，均未出现严重并发症。结论 TACE联合PMCT及TACE联合125I放射性粒子植入均为原发性大肝癌安全、有效的治疗方法，两组毒副反应及并发症的发生率相当，前者治疗效果较为理想，值得临床应用。

关键词:  肝肿瘤, 化学栓塞, 微波消融, 125I放射性粒子, 疗效

Abstract: Objective To compare the therapeutic efficacy of transcatheter arterial chemoembolization （TACE） combined with either psychro-circulation percutaneous microwave coagulation therapy or radioactive 125I particle implantation for treating large primary liver cancer （LPLC）. Methods A total of 46 patients with LPLC underwent TACE and psychro-circulation percutaneous microwave coagulation therapy using the ECO-100 system， while 20 patients underwent TACE and radioactive 125I particle implantation.At 2 and 3 months after treatment， patients were analyzed by dynamic enhanced computed tomography scanning，and adverse reactions and complications were recorded. Results At 3 months after treatment，TACE combined with psychro-circulation percutaneous microwave coagulation therapy gave a local control rate of 82.61%，compared to 55.00% for TACE combined with radioactive 125I particle implantation （P<0.05）. The two methods gave similar clinical control rates of 93.47% and 85.00%，respectively （P>0.05）.In addition，the two groups did not differ significantly in adverse reactions，and neither group showed serious complications. Conclusion TACE combined with either psychro-circulation percutaneous microwave coagulation therapy or radioactive 125I particle implantation is effective for treating LPLC，and both methods cause similar adverse reactions.Of the two combination therapies，TACE combined with psychro-circulation percutaneous microwave coagulation therapy is more effective for treating LPLC.

Key words:  Liver neoplasms, Chemoembolization, Percutaneous microwave coagulation therapy, Radioactive 125I particle implantation, Efficacy